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As a vaccine. Nineto ten-week-old BALB/c (Charles River) mice were immunized intraperitoneally with 10 g of antigen in complete Freund's adjuvant, followed by three additional 10- g doses of antigen given in incomplete Freund's adjuvant at 2-week intervals. The antigens used were purified gHt-gL produced by HL-7 cells and purified full-length gD-1 from HSV-1-infected cells (10). Sham-immunized con

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